Clonal deletion of autospecific B lymphocytes.

Nemazee, D; Russell, D; Arnold, B; Haemmerling, G; Allison, J; Miller, J F; Morahan, G; Buerki, K

Nemazee, D; Russell, D; Arnold, B; Haemmerling, G; Allison, J; Miller, J F; Morahan, G; Buerki, K.

Afiliación

Nemazee D; Dept. of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

Immunol Rev ; 122: 117-32, 1991 Aug.

Article en En | MEDLINE | ID: mdl-1937539

RESUMEN

Using mice transgenic for functional, rearranged immunoglobulin heavy and light chain genes, it can be demonstrated that B lymphocytes reactive with cell surface-bound class I MHC antigen can be controlled by clonal elimination. Even low-affinity cell-bound ligands can induce deletion. Deletion can occur in the pre-B to B cell transitional stage or after the B cells exist the bone marrow, depending on where the cells first encounter autoantigen. IgD appears to play no role in protecting cells from deletion. It is argued that defects in B-cell tolerance alone may be sufficient to lead to systemic autoimmunity.

Asunto(s)

Autoantígenos/inmunología; Linfocitos B/inmunología; Animales; Reordenamiento Génico de Cadena Pesada de Linfocito B/inmunología; Reordenamiento Génico de Cadena Ligera de Linfocito B/inmunología; Antígenos de Histocompatibilidad Clase I/inmunología; Tolerancia Inmunológica/inmunología; Ratones; Ratones Transgénicos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoantígenos / Linfocitos B Límite: Animals Idioma: En Revista: Immunol Rev Año: 1991 Tipo del documento: Article Pais de publicación: Reino Unido

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