In vitro metabolism of leflunomide by mouse and human liver microsomes.

Chan, Eric C Y; New, Lee-Sun

Chan, Eric C Y; New, Lee-Sun.

Afiliación

Chan EC; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543. phaccye@nus.edu.sg

Drug Metab Lett ; 1(4): 299-305, 2007 Dec.

Article en En | MEDLINE | ID: mdl-19356059

RESUMEN

Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated alpha-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.

Asunto(s)

Antiinflamatorios no Esteroideos/metabolismo; Isoxazoles/metabolismo; Microsomas Hepáticos/metabolismo; Compuestos de Anilina/metabolismo; Animales; Cromatografía Liquida/métodos; Crotonatos; Humanos; Hidroxibutiratos/metabolismo; Hidroxilación; Leflunamida; Masculino; Ratones; Nitrilos; Toluidinas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microsomas Hepáticos / Antiinflamatorios no Esteroideos / Isoxazoles Límite: Animals / Humans / Male Idioma: En Revista: Drug Metab Lett Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2007 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos

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