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Circulating vascular endothelial growth factors and their soluble receptors in pre-invasive, invasive and recurrent cervical cancer.
Kuemmel, Sherko; Thomas, Anke; Landt, Solveig; Fuger, Andrea; Schmid, Peter; Kriner, Monika; Blohmer, Jens-Uwe; Sehouli, Jalid; Schaller, Gerhard; Lichtenegger, Werner; Köninger, Angela; Fuchs, Ilka.
Afiliación
  • Kuemmel S; Department of Gynecology and Obstetrics, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany. Sherko.Kuemmel@uk-essen.de
Anticancer Res ; 29(2): 641-5, 2009 Feb.
Article en En | MEDLINE | ID: mdl-19331214
AIM: To study the impact of circulating vascular endothelial growth factors (VEGF) -A, -C and -D and their soluble receptors VEGFR-1/-2 on disease invasion and progression in patients with pre-invasive (CIN), invasive (PCC) and recurrent (RCC) cervical cancer. PATIENTS AND METHODS: Blood samples were obtained from 125 women, including 50 cases of CIN, 51 of PCC and 24 of RCC, before treatment. Soluble (s) biomarker levels were determined by ELISA and tested for correlation with histopathological factors. RESULTS: With disease progression, sVEGF-A (p = 0.007) and sVEGFR-2 (p = 0.014) significantly increased, while sVEGF-D (p = 0.046) decreased. sVEGFR-2 levels were increased in node+ patients (p = 0.024) and in metastatic disease (p = 0.003). sVEGF-A values were higher in HPV+ cases (p = 0.019). In detecting disease invasiveness, sensitivity and specificity were 76% and 48% for sVEGF-A, 52% and 32% for sVEGF-D, 25% and 94% for sVEGF-C, 93% and 6% for sVEGFR-1 and 73% and 34% for sVEGFR-2, respectively. CONCLUSION: In cervical neoplasia, a switch from a lymphangiogenic phenotype towards a hemangiogenic phenotype occurs with disease invasion and progression. The sensitivity and specificity values, however, seem not convincing enough to establish these factors as clinical markers for disease invasiveness in cervical cancer.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Receptor 1 de Factores de Crecimiento Endotelial Vascular / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Factor A de Crecimiento Endotelial Vascular / Recurrencia Local de Neoplasia Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Grecia
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Receptor 1 de Factores de Crecimiento Endotelial Vascular / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Factor A de Crecimiento Endotelial Vascular / Recurrencia Local de Neoplasia Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Grecia