Modulating the relaxivity of hyperpolarized substrates with gadolinium contrast agents.
Contrast Media Mol Imaging
; 4(3): 143-7, 2009.
Article
en En
| MEDLINE
| ID: mdl-19330792
Gadolinium contrast agents are known to affect the outer-sphere relaxivities of nuclei other than protons. We have investigated the heteronuclear relaxivities of four commercial gadolinium contrast agents (Magnevist, Omniscan, Dotarem and Gadovist) on the relaxation of (13)C in glycine, (13)C in pyruvate and (15)N in choline with long relaxation times. Marked differences in the relaxivities were found between different contrast agents and are attributed to electrostatic effects. This methodology may find applications in the field of hyperpolarized magnetic resonance and by way of example we show that injection of a bolus of contrast agent into an aqueous solution containing hyperpolarized (15)N labeled tetramethylammonium or (13)C labeled pyruvate leads to a predictable shortening of the lifetime of the hyperpolarized signal.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
/
Medios de Contraste
/
Gadolinio
Idioma:
En
Revista:
Contrast Media Mol Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2009
Tipo del documento:
Article
Pais de publicación:
Reino Unido