Transsplenic portal catheterization combined with a jugular double-lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs.
J Vet Pharmacol Ther
; 32(2): 137-45, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-19290943
The reliability of a silicone double-lumen catheter implanted into the external jugular vein and tunnelled towards the neck region was investigated in eight pigs. Surgery was uneventful without interference with the normal homoeostasis during 8 days. After injection of amoxicillin/clavulanic acid through the distal port of the catheter, analysis of drug components in the simultaneous blood samples obtained by the proximal port and a Venoject system were comparable in one pig. Histological control of the catheterized jugular veins pointed to an acceptable tissue reaction while bacteriological examination of the tip of the catheters was negative in only three animals. A moulding of the intestinal veins was made in a pig cadaver to determine the optimal length of insertion of a silicone portal catheter from the splenic vein towards the portal vein. Surgery was straightforward in four pigs whereby the catheter was exteriorized towards the back region. No complications were encountered during and after surgery for 9 days. The technique of a double-lumen catheter placed into the jugular vein and a transsplenic portal catheter is a useful tool for the study of the pharmacokinetics and also the first-pass effect of drugs in experimental pigs.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vena Porta
/
Porcinos
/
Cateterismo
/
Combinación Amoxicilina-Clavulanato de Potasio
/
Venas Yugulares
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
J Vet Pharmacol Ther
Año:
2009
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Reino Unido