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Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women.
Alves Corrêa, Silvana Aparecida; Ribeiro de Noronha, Samuel Marcos; Nogueira-de-Souza, Naiara Correa; Valleta de Carvalho, Cristina; Massad Costa, Ana Maria; Juvenal Linhares, José; Vieira Gomes, Mariano Tamura; Guerreiro da Silva, Ismael Dale Cotrim.
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  • Alves Corrêa SA; Molecular Gynaecology Laboratory, Department of Gynaecology, Federal University of São Paulo, Rua Pedro de Toledo, 781 - 4th Floor, São Paulo, 04039-032 SP, Brazil. silaac@biofis.epm.br
J Renin Angiotensin Aldosterone Syst ; 10(1): 51-8, 2009 Mar.
Article en En | MEDLINE | ID: mdl-19286759
INTRODUCTION: We evaluated the association between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type 1 (AT( 1))-receptor A1166C polymorphisms. METHODS: Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer. RESULTS: The frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, chi(2)); and for AT(1)receptor were:AA,AC and CC (in %: cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, chi( 2)).The results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls. CONCLUSIONS: The ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes.The ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible target for developing genetic markers for breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias de la Mama / Peptidil-Dipeptidasa A / Predisposición Genética a la Enfermedad / Receptor de Angiotensina Tipo 1 / Indio Americano o Nativo de Alaska Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Renin Angiotensin Aldosterone Syst Asunto de la revista: FISIOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias de la Mama / Peptidil-Dipeptidasa A / Predisposición Genética a la Enfermedad / Receptor de Angiotensina Tipo 1 / Indio Americano o Nativo de Alaska Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Renin Angiotensin Aldosterone Syst Asunto de la revista: FISIOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido