Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors--focus on subtypes iGlu(5-7).
Eur J Pharmacol
; 609(1-3): 1-4, 2009 May 01.
Article
en En
| MEDLINE
| ID: mdl-19285062
The kainic acid (kainate, KA) receptors belong to the class of ionotropic glutamate (iGlu) receptors in the central nervous system. Five subtypes have been identified, which have been termed KA(1,2) and iGlu(5-7). In the search for subtype selective ligands, alpha-amino-5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA), (4R)-methyl Glu (1a), and E-4-neopentylidene Glu (2f) have all previously been reported as selective agonists for the iGlu(5) receptor subtype. In this paper, we present the pharmacological evaluation of a five-compound series of (4R)-alkyl Glu analogs (1b-e,g) which may be envisaged as conformationally released designs of ATPA and 4-alkylidenes 2a-h. Most notable is the pharmacological profile for (4R)-isopentyl Glu (1g) which shows a 10-fold increase in binding affinity for the iGlu(5) receptor subtype (K(i)=20.5 nM) in comparison with its E-4-alkylidene structural isomer 2g. Furthermore, 1g displays high selectivity over other KA receptor subtypes (KA(1,2) and iGlu(6,7)), AMPA-, and NMDA receptors (2050 and >5000 fold, respectively).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Glutamato
/
Ácido Glutámico
/
Ácido Kaínico
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Dinamarca
Pais de publicación:
Países Bajos