Off-label, off-limits? Parental awareness and attitudes towards off-label use in paediatrics.
Eur J Pediatr
; 168(12): 1473-8, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19277709
Off-label drug use in paediatrics is associated with an increased risk of adverse drug reactions. Any risk-benefit analysis has to be based on value judgments that should include parents' views. However, nothing is known so far about the parents' perspective on this critical issue. Therefore, a quantitative survey with parents of healthy and chronically ill children was carried out (n = 94). Knowledge about the practise of off-label use is generally poor in both groups. Surprisingly, this is also true for the parents of children with chronic disease. Nine percent of the parents of chronically ill children and 20% of the parents of healthy children would refuse treatment with an off-label drug. Parents who have poor knowledge about the practise of off-label use tend to refuse to volunteer their child for study participation. Therefore, the information of parents on the off-label use of drugs is important to meet ethical standards and to increase the parents' acceptance of medical studies with children.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Padres
/
Conocimientos, Actitudes y Práctica en Salud
/
Uso Fuera de lo Indicado
Tipo de estudio:
Guideline
/
Qualitative_research
Aspecto:
Ethics
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Pediatr
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania