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Disappearance of gadolinium enhancement in a chemoresistant astrocytoma of the tectum after high-dose interferon beta.
Matsuno, Akira; Fujimaki, Takamitsu; Mizutani, Akiko; Ide, Fuyuaki; Tanaka, Hideki; Asano, Shuichiro; Miyawaki, Satoru; Uno, Takeshi; Tanaka, Junichi; Nakaguchi, Hiroshi; Sasaki, Mitsuyoshi; Murakami, Mineko; Yamazaki, Kazuto; Ishida, Yasuo.
Afiliación
  • Matsuno A; Department of Neurosurgery, Teikyo University Chiba Medical Center, Ichihara City, Chiba, Japan. akirakun@med.teikyo-u.ac.jp
Tumori ; 94(6): 853-5, 2008.
Article en En | MEDLINE | ID: mdl-19267105
Interferon beta 6 million units per week was administered to a patient with an aggressive astrocytoma in the tectum that was resistant to cisplatin, etoposide, vinblastine, and the oral alkylating agent temozolomide. The tumor was immunopositive for O6-methylguanine-DNA methyltransferase (MGMT). Interferon beta caused the disappearance of the gadolinium-enhanced lesion in the tectum. Interferons have apoptotic and antiangiogenic effects on tumor cells, and the lesion's disappearance may have been induced by complexes of these effects. Administration of interferon beta might have a favorable effect on tectal gliomas that are immunopositive for MGMT and resistant to chemoradiotherapy including temozolomide.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Techo del Mesencéfalo / Interferón beta / Resistencia a Antineoplásicos / Gadolinio DTPA / Antineoplásicos Límite: Adolescent / Female / Humans Idioma: En Revista: Tumori Año: 2008 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Techo del Mesencéfalo / Interferón beta / Resistencia a Antineoplásicos / Gadolinio DTPA / Antineoplásicos Límite: Adolescent / Female / Humans Idioma: En Revista: Tumori Año: 2008 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos