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Mental-stress-induced platelet activation among patients with coronary artery disease.
Reid, Graham J; Seidelin, Peter H; Kop, Willem J; Irvine, M Jane; Strauss, Bradley H; Nolan, Robert P; Lau, Herbert K; Yeo, Erik L.
Afiliación
  • Reid GJ; Department of Psychology, University of Western Ontario, Westminster Hall, London ON N6A 3K7, Canada. greid@uwo.ca
Psychosom Med ; 71(4): 438-45, 2009 May.
Article en En | MEDLINE | ID: mdl-19251865
OBJECTIVE: To study patients with coronary artery disease (CAD) scheduled for coronary angioplasty and to examine platelet activation in response to mental stress as a potential mechanism involved in the association between psychosocial factors and cardiac outcomes. Psychosocial factors have been identified as risk factors for CAD and adverse cardiac outcomes, although the underlying mechanisms are poorly understood. METHODS: Markers of platelet activation and platelet reactivity in response to experimentally induced mental stress (mental arithmetic and anger recall) were examined, using flow cytometry analysis and beta-thromboglobulin (BTG) assays among 249 CAD patients (age = 60.3 +/- 9.0 years, 15% women) who were scheduled to undergo elective percutaneous coronary intervention. RESULTS: Mental stress-induced increases in platelet activation (CD41 (GP IIb/IIIa), p = .002; percent of mononuclear cells positive for CD41, p = .01; CD62P (P-selectin) expression, p = .005; and percent platelets positive for CD62P, p < .001). The degree of platelet reactivity was not related to demographic, clinical, or psychological variables, or cardiovascular hemodynamic changes. CONCLUSIONS: Experimentally induced mental stress induced platelet activation in patients with CAD. This mechanism may partially explain the link between psychosocial variables and the development of adverse cardiac outcomes in patients with CAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Activación Plaquetaria / Enfermedad Coronaria Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Psychosom Med Año: 2009 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Activación Plaquetaria / Enfermedad Coronaria Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Psychosom Med Año: 2009 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos