Relationship between non-fibrillary amyloid precursors and cell processes in the cortical neuropil of Alzheimer patients.
Neurosci Lett
; 129(1): 119-22, 1991 Aug 05.
Article
en En
| MEDLINE
| ID: mdl-1922961
We examined the ultrastructural localization of amyloid beta-protein in 8 Alzheimer neocortical biopsies. Intense immunoreactivity was located extracellularly on amyloid fibrils and amorphous material. Amorphous labelled material was also found in cell processes. No ultrastructural cell marker, such as glial fibrils, glycogen, tubules, paired helical filaments (PFHs) or synaptic vesicles could be seen in these processes that could allow their identification as glial processes, neurites or presynaptic terminals, respectively; occasional membrane stacks were observed. These findings suggest that preamyloid deposits are related to cell processes and, by elimination, that postsynaptic terminals may be involved in abnormal metabolism of the amyloid fibril precursors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corteza Cerebral
/
Ovillos Neurofibrilares
/
Precursor de Proteína beta-Amiloide
/
Enfermedad de Alzheimer
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neurosci Lett
Año:
1991
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Irlanda