[Study on the phenotypic characteristics of Japanese encephalitis virus strains isolated from different years].
Bing Du Xue Bao
; 24(6): 427-31, 2008 Nov.
Article
en Zh
| MEDLINE
| ID: mdl-19226950
In order to reveal the phenotypic characteristics of 17 JE virus strains isolated from different years, plaque sizes, mice neurovirulence and mice neuroinvasiveness of the isolates were studied and compared. BHK21 cell monolayers were used for testing the plaque sizes. The virus neurovirulence was tested in 9-11g mice inoculated intracerebrally and the virus neuroinvasiveness was tested in 9-11g and 14-16g by subcutaneous inoculation. Results showed that all the viruses produced clear plaques on the BHK21 cell monolayers with different sizes and all the virus strains appeared high neurovirulence in the mice with higher than lg8. 0/0.03 mL virus titers, while no apparent difference among them. The neuroinvasiveness (subcutaneous virulence) tested in the 9-11g mice had shown a little difference, but when tested in the 12-14 g mice,the difference was apparent. The results demonstrated that JEV in nature were highly neurovirulent with no apparent difference. However the neuroinvasiveness of the JEV in nature was greatly different, which didn't relate to the years of isolation and genotypes, but most of the viruses isolated from patients showed higher neuroinvasiveness.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encefalitis Japonesa
/
Virus de la Encefalitis Japonesa (Especie)
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Bing Du Xue Bao
Asunto de la revista:
VIROLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China