MAP'ing CNS development and cognition: an ERKsome process.
Neuron
; 61(2): 160-7, 2009 Jan 29.
Article
en En
| MEDLINE
| ID: mdl-19186160
The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Discapacidades del Desarrollo
/
Trastornos del Conocimiento
/
Sistema de Señalización de MAP Quinasas
/
Quinasas MAP Reguladas por Señal Extracelular
Límite:
Animals
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos