The genetic control of the formation and propagation of the [PSI+] prion of yeast.
Prion
; 1(2): 101-9, 2007.
Article
en En
| MEDLINE
| ID: mdl-19164924
It is over 40 years since it was first reported that the yeast Saccahromyces cerevisiae contains two unusual cytoplasmic 'genetic' elements: [PSI(+)] and [URE3]. Remarkably the underlying determinants are protein-based rather than nucleic acid-based, i.e., that they are prions, and we have already learnt much about their inheritance and phenotypic effects from the application of 'classical' genetic studies alongside the more modern molecular, cellular and biochemical approaches. Of particular value has been the exploitation of chemical mutagens and 'antagonistic' mutants which directly affect the replication and/or transmission of yeast prions. In this Chapter we describe what has emerged from the application of classical and molecular genetic studies, to the most intensively studied of the three native yeast prions, the [PSI(+)] prion.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
Priones
/
Citoplasma
/
Proteínas de Saccharomyces cerevisiae
/
Mutación
Idioma:
En
Revista:
Prion
Asunto de la revista:
BIOQUIMICA
Año:
2007
Tipo del documento:
Article
Pais de publicación:
Estados Unidos