A new atisane-type diterpene from the bark of the mangrove plant Excoecaria agallocha.

Wang, Zhan Chang; Lin, Yi Ming; Feng, Dan Qin; Ke, Cai Huan; Lin, Peng; Yan, Chong Ling; Chen, Jun De

Wang, Zhan Chang; Lin, Yi Ming; Feng, Dan Qin; Ke, Cai Huan; Lin, Peng; Yan, Chong Ling; Chen, Jun De.

Afiliación

Wang ZC; Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, China.

Molecules ; 14(1): 414-22, 2009 Jan 16.

Article en En | MEDLINE | ID: mdl-19158653

RESUMEN

A new atisane-type diterpene, ent-16alpha-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16alpha-hydroxy-atisane-3-one (1), ent-atisane-3beta,16alpha-diol (2), ent-3,4-seco-16alpha-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC(50) value of 0.54+/-0.01 ppm.

Asunto(s)

Diterpenos/aislamiento & purificación; Euphorbiaceae/química; Corteza de la Planta/química; Animales; Biopelículas; Diterpenos/química; Humanos; Espectrometría de Masas/métodos; Modelos Moleculares; Resonancia Magnética Nuclear Biomolecular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Euphorbiaceae / Corteza de la Planta / Diterpenos Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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