Anti-elastin antibodies and elastin turnover in normal pregnancy and recurrent pregnancy loss.
Am J Reprod Immunol
; 61(2): 167-74, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-19143680
PROBLEM: The aim of this study was to investigate elastin turnover and autoimmunity in patients with a history of recurrent pregnancy loss (RPL) and during normal pregnancy. METHOD OF STUDY: Anti-alpha-elastin and anti-tropoelastin IgG and IgM antibodies were measured by a home-made ELISA in serum samples of 60 medically and obstetrically normal pregnant women, classified to three trimester groups, 18 female patients with RPL and 18 healthy non-pregnant women with a history of successful pregnancies. One way analyses of variance and Least Significant Difference method were used for a statistical analysis. RESULTS: Anti-alpha-elastin IgG autoantibodies were significantly decreased in the third trimester pregnant women. IgM anti-alpha-elastin autoantibodies were significantly decreased in all pregnancy groups compared with the controls. Synthesis/degradation ratio of elastin was significantly increased in the third trimester pregnancy group, suggesting decreased elastin degradation during this period of pregnancy. Comparing the RPL patients with the healthy non-pregnant controls showed a significantly increased anti-alpha-elastin IgG antibody and significantly decreased synthesis/degradation ratio in the patient's group, suggesting increased elastin degradation in RPL. CONCLUSION: Elastin degradation is decreased during normal pregnancy. Increased anti-elastin IgG antibodies may contribute to the pathogenesis of pregnancy losses.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Aborto Habitual
/
Elastina
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Adult
/
Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Reprod Immunol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Bulgaria
Pais de publicación:
Dinamarca