Genetic analysis of group A streptococcus isolates recovered during acute glomerulonephritis outbreaks in Guizhou Province of China.
J Clin Microbiol
; 47(3): 715-20, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19116348
In this study, 68 group A streptococcus (GAS) isolates associated with two outbreaks of acute glomerulonephritis (AGN) in China were analyzed by emm typing. A total of 11 different emm types were identified. Analysis of emm type distribution suggested that AGN outbreaks in two counties were caused by emm60.1- and emm63.0-type GAS. These two types were further characterized by pulsed-field gel electrophoresis, multilocus sequence typing, sof sequence typing, and PCR-based identification of streptococcal pyrogenic exotoxin A, B, and C (speA, speB, and speC) genes. In antimicrobial susceptibility tests, all outbreak strains were resistant to erythromycin and tetracycline, and the rates of resistance of nonoutbreak strains to the two antibiotics were 63.6% and 90.9%. This study is also the first to report a nephritogenic M63 GAS strain.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Estreptocócicas
/
Streptococcus pyogenes
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Brotes de Enfermedades
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Glomerulonefritis
Límite:
Adolescent
/
Animals
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Child
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Child, preschool
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Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Clin Microbiol
Año:
2009
Tipo del documento:
Article
Pais de publicación:
Estados Unidos