Biorecognition of Escherichia coli K88 adhesin for glycated porcine albumin.
Int J Biol Macromol
; 44(2): 175-81, 2009 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-19101589
Escherichia coli (E. coli) that expresses galactose-reactive lectins, like K88 adhesin, causes high mortality among piglets. Carbohydrates that compete for adhesion could serve as an alternative for disease prevention. Porcine serum albumin (PSA) was modified by non-enzymatic glycation with lactose to produce PSA-Lac or PSA-Glc beta (1-4) Gal, as confirmed by reduction of available free amino groups, increased molecular mass and by Ricinus communis lectin recognition. E. coli K88 binds to PSA-Lac treatments containing three and four lactoses, respectively. In addition, PSA-Lac partially inhibited K88 strain adherence to mucins. These results suggest that neoglycoconjugates obtained by non-enzymatic glycation of proteins may serve in the prophylaxis of piglets' diarrhea.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Albúmina Sérica
/
Adhesinas de Escherichia coli
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Proteínas de Escherichia coli
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Proteínas Fimbrias
/
Antígenos Bacterianos
Límite:
Animals
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2009
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Países Bajos