Identification and characterization of two zebrafish nectin-1 genes that are differentially expressed in the developing eye and brain.
Dev Dyn
; 238(1): 43-55, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-19097185
Nectins are cell adhesion molecules of the immunoglobulin type that play important roles in the development of the nervous system. We have characterized two paralogous zebrafish nectin-1 genes, nectin-1a and nectin-1b, that differ in expression. Nectin-1a expression is first found in the anterior neural keel and later in the optic cup. In the retina, nectin-1a appears in the outer part and extends inwards, while nectin-1b starts in the inner part and spreads outwards. Only nectin-1a was detected in the cornea, the lens, and in the region of photoreceptor cell differentiation in the retina. Both genes were expressed in ganglion cells and inner nuclear neurons. In the brain, nectin-1a was restricted to the epiphysis and a cluster of cells in the posterior hindbrain, whereas nectin-1b was found in several brain areas. Zebrafish may, therefore, be a useful model for identifying different functions of nectin-1 in the developing eye and nervous system.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pez Cebra
/
Encéfalo
/
Moléculas de Adhesión Celular
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Regulación del Desarrollo de la Expresión Génica
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Isoformas de Proteínas
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Proteínas de Pez Cebra
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Ojo
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Dev Dyn
Asunto de la revista:
ANATOMIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Noruega
Pais de publicación:
Estados Unidos