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Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.
Adachi, Hironori; Fujiwara, Yukio; Kondo, Tatsuya; Nishikawa, Takeshi; Ogawa, Rei; Matsumura, Takeshi; Ishii, Norio; Nagai, Ryoji; Miyata, Keishi; Tabata, Mitsuhisa; Motoshima, Hiroyuki; Furukawa, Noboru; Tsuruzoe, Kaku; Kawashima, Junji; Takeya, Motohiro; Yamashita, Shizuya; Koh, Gou Young; Nagy, Andras; Suda, Toshio; Oike, Yuichi; Araki, Eiichi.
Afiliación
  • Adachi H; Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
Biochem Biophys Res Commun ; 379(4): 806-11, 2009 Feb 20.
Article en En | MEDLINE | ID: mdl-19094966
Angiopoietin-like protein family 4 (Angptl 4) has been shown to regulate lipoprotein metabolism through the inhibition of lipoprotein lipase (LPL). We generated ApoE(-/-)Angptl 4(-/-) mice to study the effect of Angptl 4 deficiency on lipid metabolism and atherosclerosis. Fasting and postolive oil-loaded triglyceride (TG) levels were largely decreased in ApoE(-/-)Angptl 4(-/-) mice compared with and ApoE(-/-)Angptl 4(+/+) mice. There was a significant (75+/-12%) reduction in atherosclerotic lesion size in ApoE(-/-)Angptl 4(-/-) mice compared with ApoE(-/-) Angptl 4(+/+) mice. Peritoneal macrophages, isolated from Angptl 4(-/-) mice to investigate the foam cell formation, showed a significant decrease in newly synthesized cholesteryl ester (CE) accumulation induced by acetyl low-density lipoprotein (acLDL) compared with those from Angptl 4(+/+) mice. Thus, genetic knockout of Angptl 4 protects ApoE(-/-) mice against development and progression of atherosclerosis and strongly suppresses the ability of the macrophages to become foam cells in vitro.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Macrófagos Peritoneales / Angiopoyetinas / Aterosclerosis / Metabolismo de los Lípidos / Células Espumosas Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2009 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Macrófagos Peritoneales / Angiopoyetinas / Aterosclerosis / Metabolismo de los Lípidos / Células Espumosas Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2009 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos