Molecular analysis of MHC-class-I alterations in human tumor cell lines.
Int J Cancer Suppl
; 6: 123-30, 1991.
Article
en En
| MEDLINE
| ID: mdl-1906050
Molecular characterization of HLA-class-I expression was investigated in human tumor cell lines at the protein and mRNA levels using locus-specific monoclonal antibodies (MAbs) and probes. Some cell lines exhibited a differential expression of HLA-A and HLA-B products and also showed differences in the inducibility of HLA-class-I genes by gamma-IFN. Thus, gamma-IFN stimulation induced predominantly HLA-B mRNA in the HeP-2 cell line, which showed imbalances in basal levels of HLA-A and HLA-B expression. This unequal inducibility of HLA genes may imply that locus-specific regulatory mechanisms are involved in the expression of individual HLA products. The specific mechanism controlling the differential expression of HLA subsets appears to be independent of c-myc activity. Northern blot analysis found no relationship between c-myc mRNA levels and specific mRNA for HLA-A and HLA-B antigens.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Genes MHC Clase I
/
Antígenos de Histocompatibilidad Clase I
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Int J Cancer Suppl
Asunto de la revista:
NEOPLASIAS
Año:
1991
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Estados Unidos