Your browser doesn't support javascript.
loading
Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells.
Loizzo, M R; Tundis, R; Menichini, F; Saab, A M; Statti, G A; Menichini, F.
Afiliación
  • Loizzo MR; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende (CS), Italy, andChemistry Department, Faculty of Sciences II, Lebanese University, Fanar, Beirut, Lebanon.
  • Tundis R; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende (CS), Italy, andChemistry Department, Faculty of Sciences II, Lebanese University, Fanar, Beirut, Lebanon.
  • Menichini F; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende (CS), Italy, andChemistry Department, Faculty of Sciences II, Lebanese University, Fanar, Beirut, Lebanon.
  • Saab AM; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende (CS), Italy, andChemistry Department, Faculty of Sciences II, Lebanese University, Fanar, Beirut, Lebanon.
  • Statti GA; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende (CS), Italy, andChemistry Department, Faculty of Sciences II, Lebanese University, Fanar, Beirut, Lebanon.
  • Menichini F; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende (CS), Italy, andChemistry Department, Faculty of Sciences II, Lebanese University, Fanar, Beirut, Lebanon.
Cell Prolif ; 41(6): 1002-1012, 2008 Dec.
Article en En | MEDLINE | ID: mdl-19040575
OBJECTIVES: The purpose of this study was to evaluate cytotoxic activity of Platycladus orientalis, Prangos asperula and Cupressus sempervirens ssp. pyramidalis essential oils and to identify active components involved in inhibition of population growth of human cancer cell lines. MATERIALS AND METHODS: Essential oils were obtained by hydrodistillation and were analysed by gas chromatography and gas chromatography coupled to mass spectrometry. Antiproliferative activity was tested on amelanotic melanoma C32 cells and on renal cell adenocarcinoma cells, using the sulphorhodamine B assay. RESULTS: Cupressus sempervirens ssp. pyramidalis leaf oil exerted the highest cytotoxic activity with an IC(50)value of 104.90 microg/mL against C32, followed by activity of P. orientalis and P. asperula on the renal adenocarcinoma cell line (IC(50) of 121.93 and 139.17 microg/mL, respectively). P. orientalis essential oil was also active against amelanotic melanoma with an IC(50) of 330.04 microg/mL. Three identified terpenes, linalool, beta-caryophyllene and alpha-cedrol, were found to be active on both cell lines tested. CONCLUSIONS: Our findings provide novel insights into the field of cytotoxic properties of essential oils. This study provided evidence on how cytotoxic activity of the oils is not always related to their major constituents, except for lower activity found in both cell lines for alpha-cedrol. Interestingly, beta-caryophyllene and linalool exhibited comparable IC(50) values to the commercial drug vinblastine on the ACHN cell line. This opens a new field of investigation to discover mechanisms responsible for the observed activity.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Aceites Volátiles / Carcinoma de Células Renales / Melanoma Amelanótico / Neoplasias Renales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Prolif Año: 2008 Tipo del documento: Article País de afiliación: Líbano Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Aceites Volátiles / Carcinoma de Células Renales / Melanoma Amelanótico / Neoplasias Renales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Prolif Año: 2008 Tipo del documento: Article País de afiliación: Líbano Pais de publicación: Reino Unido