A proteomic approach for studying the pathogenesis of spontaneous equine recurrent uveitis (ERU).
Vet Immunol Immunopathol
; 128(1-3): 132-6, 2009 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-19026452
Equine recurrent uveitis (ERU) is a wide spread disease of the eye, which is the main cause for blindness in horses worldwide. Meanwhile, ERU is also accepted as the only reliable spontaneous model for human autoimmune uveitis. We identified and characterized novel autoantigens by analyzing the autoantibody-binding pattern from ERU cases to the retinal proteome. Cellular retinaldehyde-binding protein (CRALBP) and malate dehydrogenase (MDH) were detected as novel ERU autoantigens by this approach. B- and T-cell autoreactivity was detected to both autoantigens in ERU cases. The evaluation of the pathological relevance of CRALBP and MDH brought surprising results. While CRALBP-induced uveitis with high incidence in rats and horses, MDH was only uveitogenic in Lewis rats, but not in the horse itself.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Uveítis
/
Proteómica
/
Enfermedades de los Caballos
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Vet Immunol Immunopathol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Países Bajos