Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis.

Rossi, Giulio; Sartori, Giuliana; Cavazza, Alberto; Tamberi, Stefano

Rossi, Giulio; Sartori, Giuliana; Cavazza, Alberto; Tamberi, Stefano.

Lung Cancer ; 63(1): 159-60, 2009 Jan.

Article en En | MEDLINE | ID: mdl-18992960

RESUMEN

Mucoepidermoid carcinoma (MEC) of the lung needs to be carefully distinguished from other lung tumors with similar features, particularly from adenosquamous carcinoma, this latter tumor frequently showing EGFR mutations. In contrast with the data reported by Han et al in the last July issue of Lung Cancer, neither EGFR nor K-RAS mutations were observed in MEC from caucasian patients.

Asunto(s)

Carcinoma Mucoepidermoide/tratamiento farmacológico; Carcinoma Mucoepidermoide/genética; Receptores ErbB/antagonistas & inhibidores; Receptores ErbB/genética; Genes ras; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Anciano; Carcinoma Mucoepidermoide/diagnóstico; Diagnóstico Diferencial; Epitelio/metabolismo; Femenino; Humanos; Queratinas/metabolismo; Neoplasias Pulmonares/diagnóstico; Mucina 5AC/metabolismo; Mucinas/metabolismo; Mutación

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genes ras / Carcinoma Mucoepidermoide / Receptores ErbB / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies Límite: Aged / Female / Humans Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2009 Tipo del documento: Article Pais de publicación: Irlanda

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