Prostaglandin E2-hemoglobin AA and SS erythrocyte interaction (prostaglandin-erythrocyte interaction).
Am J Hematol
; 2(2): 133-43, 1977.
Article
en En
| MEDLINE
| ID: mdl-18932
Prostaglandin E2 (PGE2), at concentration larger than or equal to 5 x 10(4) ng/ml, induced discocyte leads to echinocyte transformation of saline-suspended hemoglobin (Hb) AA and SS erythrocytes. This erythrocyte transformation is concentration-dependent and is reversible at room temperature after 90-120 min. The Hb SS erythrocytes treated with PGE2 did not exhibit accelerated sickling or increased formation of sickled echinocytes. Erythrocytes suspended in autologous plasma treated with PGE2, 2 X 10(6) ng/ml, did not exhibit echinocytic transformation probably because of drug binding to the plasma proteins. Other in vitro studies showed that PGE2 of concentrations of 10-500 ng/ml had no adverse effects on intact, plasma-suspended Hb SS erythrocytes. These Hb SS erythrocytes were examined for changes in morphology, potassium and calcium flux, and blood viscosity under oxygenated and hypoxic conditions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prostaglandinas E
/
Eritrocitos Anormales
/
Anemia de Células Falciformes
Límite:
Humans
Idioma:
En
Revista:
Am J Hematol
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Estados Unidos