Radiolytic one-electron reduction characteristics of tyrosine derivative caged by 2-oxopropyl group.

Tanabe, Kazuhito; Ebihara, Masahiko; Hirata, Nao; Nishimoto, Sei-ichi

Tanabe, Kazuhito; Ebihara, Masahiko; Hirata, Nao; Nishimoto, Sei-ichi.

Afiliación

Tanabe K; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan. tanabeka@scl.kyoto-u.ac.jp

Bioorg Med Chem Lett ; 18(23): 6126-9, 2008 Dec 01.

Article en En | MEDLINE | ID: mdl-18930655

RESUMEN

We employed X-irradiation to activate a caged amino acid with a 2-oxoalkyl group. We designed and synthesized tyrosine derivative caged by a 2-oxoalkyl group (Tyr(Oxo)) to evaluate its radiolytic one-electron reduction characteristics in aqueous solution. Upon hypoxic X-irradiation, Tyr(Oxo) released a 2-oxopropyl group to form the corresponding uncaged tyrosine. In addition, radiolysis of dipeptides containing Tyr(Oxo) revealed that the efficiency of radiolytic removal of 2-oxopropyl group increased significantly by the presence of neighboring aromatic amino acids.

Asunto(s)

Aminoácidos/química; Tirosina/química; Dipéptidos/efectos de la radiación; Estructura Molecular; Oxidación-Reducción; Propano/análogos & derivados; Propano/química; Relación Estructura-Actividad; Tirosina/efectos de la radiación; Rayos X

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirosina / Aminoácidos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2008 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google