Effects of the angiotensin converting enzyme inhibitor, benazepril, on the sino-aortic baroreceptor heart rate reflex.

West, J N; Champion de Crespigny, P C; Stallard, T J; Littler, W A

West, J N; Champion de Crespigny, P C; Stallard, T J; Littler, W A.

Afiliación

West JN; Department of Cardiovascular Medicine, University of Birmingham, Queen Elizabeth Hospital, UK.

Cardiovasc Drugs Ther ; 5(4): 747-51, 1991 Aug.

Article en En | MEDLINE | ID: mdl-1888695

RESUMEN

The effects of monotherapy with the angiotensin converting enzyme inhibitor benazepril (10 mg once daily) on cardiovascular baroreceptor reflexes were determined in 10 patients with essential hypertension using a randomized, double-blind, placebo-controlled, cross-over protocol. Early sino-aortic baroreceptor/heart rate reflex resetting was apparent with acute treatment; this effect persisted throughout the active treatment period. Changes in baroreflex sensitivity did not appear to mediate the hypotensive effect of benazepril.

Asunto(s)

Inhibidores de la Enzima Convertidora de Angiotensina/farmacología; Antihipertensivos/farmacología; Benzazepinas/farmacología; Presorreceptores/efectos de los fármacos; Benzazepinas/sangre; Método Doble Ciego; Femenino; Frecuencia Cardíaca/efectos de los fármacos; Humanos; Masculino; Persona de Mediana Edad; Reflejo/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presorreceptores / Benzazepinas / Inhibidores de la Enzima Convertidora de Angiotensina / Antihipertensivos Tipo de estudio: Clinical_trials / Guideline Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Cardiovasc Drugs Ther Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / TERAPIA POR MEDICAMENTOS Año: 1991 Tipo del documento: Article Pais de publicación: Estados Unidos

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