Profound pain reduction after induction of memantine treatment in two patients with severe phantom limb pain.
Anesth Analg
; 107(4): 1377-9, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18806054
We present the cases of two patients who suffered severe lower extremity injuries and subsequently developed phantom limb pain (PLP) that was refractory to high dose opioids and adjunctive pain medications. Both patients were receiving large doses of oral methadone, IV hydromorphone via a patient-controlled analgesia delivery system, and adjunctive medications including tricyclic antidepressants, nonsteroidal anti-inflammatory medications, and anti-epileptics. Despite these treatments, the patients had severe PLP. Upon induction of the oral N-methyl-D-aspartate receptor antagonist memantine, both patients had a profound reduction in their PLP without any apparent side effects from the medication.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Miembro Fantasma
/
Memantina
/
Receptores de N-Metil-D-Aspartato
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Anesth Analg
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos