Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility.
Fertil Steril
; 92(2): 541-7, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-18774560
OBJECTIVE: To examine whether a relationship exists between genetic polymorphisms of glutathione S-transferase (GST) M1 and T1, CYP1A1(*)2C, and male factor infertility. DESIGN: Genetic polymorphism analysis, case-control study. SETTING: University research laboratory and andrology clinic. PATIENT(S): One hundred ten men with infertility and 105 healthy fertile men were recruited for the study. INTERVENTION(S): Physical examination of the genitalia of patients, scrotal colored Doppler ultrasound examination, and blood sampling were performed for DNA extraction and genotyping. MAIN OUTCOME MEASURE(S): CYP1A1(*)2C, GSTM1, and GSTT1 polymorphism genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism methods. Seminal parameters were analyzed. RESULT(S): There were significant differences between infertility and GSTM1, CYP1A1(*)2C genotypes by univariate analyses. A subject carrying CYP1A1 Val/Val or CYP1A1 Ile/Val in association with GSTM null genotype has 6.90 times more risk to be infertile than a subject carrying CYP1A1 Ile/Ile in association with GSTM1 wild-type genotype (odds ratio: 6.90, 95% confidence interval: 2.29-19.3). No correlation was found between the seminal parameters and the genetic variability. CONCLUSION: Our results suggest that genetic polymorphisms of xenobiotic-metabolizing enzymes could play an important role in infertility.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Citocromo P-450 CYP1A1
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Glutatión Transferasa
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Infertilidad Masculina
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fertil Steril
Año:
2009
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Estados Unidos