Your browser doesn't support javascript.
loading
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
Sakae, Nobutaka; Yamasaki, Nobuyuki; Kitaichi, Kiyoyuki; Fukuda, Takaichi; Yamada, Mitsunori; Yoshikawa, Hiroo; Hiranita, Takato; Tatsumi, Yoshiki; Kira, Jun-ichi; Yamamoto, Tsuneyuki; Miyakawa, Tsuyoshi; Nakayama, Keiichi I.
Afiliación
  • Sakae N; Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-2-2 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Hum Mol Genet ; 17(20): 3191-203, 2008 Oct 15.
Article en En | MEDLINE | ID: mdl-18647754
FEZ1 (fasciculation and elongation protein zeta 1), a mammalian ortholog of Caenorhabditis elegans UNC-76, interacts with DISC1 (disrupted in schizophrenia 1), a schizophrenia susceptibility gene product, and polymorphisms of human FEZ1 have been associated with schizophrenia. We have now investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1. Immunofluorescence staining revealed FEZ1 to be located predominantly in gamma-aminobutyric acid-containing interneurons. The Fez1(-/-) mice showed marked hyperactivity in a variety of behavioral tests as well as enhanced behavioral responses to the psychostimulants MK-801 and methamphetamine. In vivo microdialysis revealed that the methamphetamine-induced release of dopamine in the nucleus accumbens was exaggerated in the mutant mice, suggesting that enhanced mesolimbic dopaminergic transmission contributes to their hyperactivity phenotype. These observations implicate impairment of FEZ1 function in the pathogenesis of schizophrenia.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Proteínas de Unión al ADN / Proteínas del Tejido Nervioso Tipo de estudio: Risk_factors_studies Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2008 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Proteínas de Unión al ADN / Proteínas del Tejido Nervioso Tipo de estudio: Risk_factors_studies Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2008 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido