[Studies on the antitumor antibiotic aclacinomycin A].
Wei Sheng Wu Xue Bao
; 31(3): 247-50, 1991 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-1862654
During the course of screening for new antitumor antibiotics, a new anthracycline antibiotic--aclacinomycin A was separated from the broth and mycelium of Streptomyces AC-57. The strain AC-57 was isolated from the soil collected in the Shanghai suburbs. According to its culture and physiological characteristics the producer was identified as Str. galilaeus AC-57. The broth and mycelium were extracted and treated with solvents as usual way. The aclacinomycin A was separated by silica-gel column chromatography eluted with chrolo-form-methanol. Aclacinomycin A, its aglycone and sugar components were identified by comparison of their physico-chemical and spectral data (MS, UV, IR, 1H-NMR, and 13C-NMR) with authentic compound, purified from the market sample.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Aclarubicina
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Wei Sheng Wu Xue Bao
Año:
1991
Tipo del documento:
Article
Pais de publicación:
China