Serotoninergic mechanisms of the effects of neurotensin on passive avoidance behavior in rats.
Neurosci Behav Physiol
; 38(5): 517-21, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18607747
The aim of the present work was to identify the features of the actions of neurotensin on administration into the substantia nigra or dorsal cervical nucleus on the reproduction of passive avoidance reactions in rats. The results showed that the action of neurotensin administered into the substantia nigra was accompanied by sharp reductions in passive avoidance reactions, while administration into the dorsal cervical nucleus, conversely, led to increases in these reactions and slowing of their extinction. The effects of microinjections of the serotonin 5-HT(1A) receptor agonist 8-hydroxydipropylaminotetraline (8-OH-DPAT) into these brain structures were analogous to the effects of neurotensin. The different behavioral effects of administration of neurotensin corresponded to identifiable changes in the levels of serotonin and its metabolite 5-hydroxyindoleacetic acid in the caudate nuclei of the brain. These data led to the conclusion that the effects of neurotensin on passive avoidance behavior are associated with the regulation of the emotional state of the animals via actions on the functions of brain serotoninergic structures.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reacción de Prevención
/
Neurotensina
/
Sustancia Negra
/
8-Hidroxi-2-(di-n-propilamino)tetralin
/
Agonistas de Receptores de Serotonina
/
Receptor de Serotonina 5-HT1A
Límite:
Animals
Idioma:
En
Revista:
Neurosci Behav Physiol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Estados Unidos