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Successful aging in a 70-year-old man with down syndrome: a case study.
Krinsky-McHale, Sharon J; Devenny, Darlynne A; Gu, Hong; Jenkins, Edmund C; Kittler, Phyllis; Murty, Vundavalli V; Schupf, Nicole; Scotto, Luigi; Tycko, Benjamin; Urv, Tiina K; Ye, Lingling; Zigman, Warren B; Silverman, Wayne.
Afiliación
  • Krinsky-McHale SJ; New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA. sharon.krinsky-mchale@omr.state.ny.us
Intellect Dev Disabil ; 46(3): 215-28, 2008 Jun.
Article en En | MEDLINE | ID: mdl-18578579
The authors present a case study of a 70-year-old man with Down syndrome ("Mr. C.") who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Logro / Envejecimiento / Síndrome de Down / Cognición Límite: Aged / Humans / Male Idioma: En Revista: Intellect Dev Disabil Asunto de la revista: TRANSTORNOS MENTAIS Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Logro / Envejecimiento / Síndrome de Down / Cognición Límite: Aged / Humans / Male Idioma: En Revista: Intellect Dev Disabil Asunto de la revista: TRANSTORNOS MENTAIS Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos