Completely mismatched allogeneic CD3/CD28 cross-linked Th1 memory cells elicit anti-leukemia effects in unconditioned hosts without GVHD toxicity.
Leuk Res
; 32(12): 1903-13, 2008 Dec.
Article
en En
| MEDLINE
| ID: mdl-18565579
Fully allogeneic CD3/CD28 cross-linked Th1 cells were found to elicit host-mediated anti-leukemia effects without GVHD toxicity. Mice inoculated with a lethal dose of BCL1 leukemia demonstrated significantly enhanced survival after allogeneic Th1 treatment. Cure rates of 12.5% with a single allogeneic cell infusion and 31.25% with multiple infusions were demonstrated. Cured mice were able to reject rechallenge with a lethal dose of tumor without further treatment. These results suggest that use of intentionally mis-matched, Th1 memory cells infused with cross-linked CD3/CD28 could represent a novel clinical approach to eliciting potent anti-tumor effects in patients without conditioning and without GVHD toxicity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia Linfocítica Crónica de Células B
/
Células TH1
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Efecto Injerto vs Leucemia
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Enfermedad Injerto contra Huésped
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Memoria Inmunológica
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Leuk Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Israel
Pais de publicación:
Reino Unido