[Torcetrapib increases mortality in patients with a high risk of cardiovascular disorders]. / Torcetrapib verhoogt sterfte bij patiënten met een toegenomen risico op cardiovasculaire aandoeningen.
Ned Tijdschr Geneeskd
; 152(19): 1088-90, 2008 May 10.
Article
en Nl
| MEDLINE
| ID: mdl-18552062
Inhibition of cholesteryl ester transfer protein (CETP) is generally regarded as a promising strategy to reduce atherosclerosis by increasing HDL cholesterol. Therefore, the potent CETP inhibitor torcetrapib was given in addition to atorvastatin in half of the 15,067 patients with a high cardiovascular risk in the randomized, double-blind 'Investigation of lipid level management to understand its impact in atherosclerotic events' (ILLUMINATE) study. Torcetrapib caused a large increase of 72.1% in HDL cholesterol and a concomitant reduction of 24.9% in LDL-cholesterol. However, the trial was terminated prematurely because of an increased risk of cardiovascular events and death. Besides increasing blood pressure, torcetrapib decreased potassium and increased sodium, bicarbonate and aldosterone in serum. Post hoc analyses showed an increased risk of death in patients whose change in electrolytes was greater than the median change. These adverse effects of torcetrapib are presumably compound-specific, but should be taken into account in future studies with novel CETP inhibitors. Furthermore, it is suggested that the efficacy of CETP inhibition with regard to cardiovascular event reduction may depend on the lipid profile of the patient.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Equilibrio Hidroelectrolítico
/
Enfermedades Cardiovasculares
/
Anticolesterolemiantes
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Año:
2008
Tipo del documento:
Article
Pais de publicación:
Países Bajos