Protecting the next generation: what is the role of the duration of human papillomavirus vaccine-related immunity?
J Infect Dis
; 197(12): 1653-61, 2008 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-18513154
BACKGROUND: There is strong evidence that human papillomavirus (HPV) is necessary for the development of cervical cancer. A prophylactic HPV vaccine with high reported efficacy was approved in North America in 2006. METHODS: A mathematical model of HPV transmission dynamics was used to simulate different scenarios of natural disease outcomes and intervention strategies. A sensitivity analysis was performed to compensate for uncertainties surrounding key epidemiological parameters. RESULTS: The expected impact that HPV vaccines have on cervical cancer incidence and HPV prevalence in the province of British Columbia in Canada revealed that, for lifelong vaccine-related protection, an immunization routine targeting younger females (grade 6), combined with a 3-year program for adolescent females (grade 9), is the most effective strategy. If vaccine-related protection continues for <10 years, then the targeting of adolescent females would be more beneficial than the targeting of younger females. The incremental benefit if boys, as well as girls, are vaccinated is small. CONCLUSIONS: Optimization of the design of immunization strategies for treatment of HPV depends substantially on the duration of vaccine-induced immunity. Given the uncertainty in estimating this duration, it may be prudent to assume a value close to the lower limit reported and adjust the program when more-accurate information for the length of vaccine-induced immunity becomes available.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Papillomavirus
/
Alphapapillomavirus
/
Vacunas contra Papillomavirus
Tipo de estudio:
Incidence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
/
Child
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Female
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Humans
/
Male
Idioma:
En
Revista:
J Infect Dis
Año:
2008
Tipo del documento:
Article
Pais de publicación:
Estados Unidos