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Harmonization of fibrinogen assay results: study within the framework of the Dutch project 'Calibration 2000'.
van den Besselaar, A M H P; Haas, F J L M; van der Graaf, F; Kuypers, A W H M.
Afiliación
  • van den Besselaar AM; Department of Thrombosis and Hemostasis, Leiden University Medical Centre, PO Box 9600, Leiden 2300 RC, The Netherlands. a.m.h.p.van_den_besselaar@lumc.nl
Int J Lab Hematol ; 31(5): 513-20, 2009 Oct.
Article en En | MEDLINE | ID: mdl-18498387
In a Dutch project for harmonization of fibrinogen assays, the commutability of potential calibrators for fibrinogen was assessed by means of a twin-study design, which is, in essence, a multicentre, split-patient sample, between-field-methods protocol. The study consisted of simultaneous analysis of fresh-frozen patient plasmas and three potential calibrators for fibrinogen by 48 Dutch laboratories forming 24 couples. The state-of-the-art intralaboratory standard deviation was used to assess the commutability of the potential calibrators. The potential calibrators were commutable for the Clauss, but not for the prothrombin time (PT)-derived assays. One potential calibrator was used in an attempt to harmonize fibrinogen assay results in a Dutch field study. The interlaboratory coefficient of variation (CV) of three out of four test samples could be reduced significantly using the common calibrator. The average overall CV for the four test samples was 10.3% using the routine measurements and 7.8% using the common calibrator. Despite the reduction in the overall CV, the bias between Clauss and PT-derived assay results in two coumarin test samples could not be eliminated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calibración / Fibrinógeno Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calibración / Fibrinógeno Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido