[Effect of neoadjuvant chemotherapy on ERCC1 gene expression in breast cancer].
Nan Fang Yi Ke Da Xue Xue Bao
; 28(4): 603-5, 2008 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-18495602
OBJECTIVE: To investigate the expression of ERCC1 gene in breast cancer before and after neo-adjuvant chemotherapy. METHODS: The expression of ERCC1 gene was detected by RT-PCR in 40 breast cancer patients and in 14 patients treated with neoadjuvant chemotherapy. RESULTS: Positive expression of ERCC1 gene was detected by RT-PCR in 35.0% of the breast cancer specimens, and ERCC1 expression was not correlated to the patients' age, tumor size, axillary lymph node metastasis, pathological type, histological grade, ER, PR or HER-2 (P>0.05). ERCC1 gene expression was significantly higher in neo-adjuvant chemotherapy group than in non-chemotherapy group (P<0.05). CONCLUSION: The expression of ERCC1 gene does not affect the clinical and pathological features of breast cancer. Neo-adjuvant chemotherapy can increase the expression of ERCC1 gene, due attention should be given to with in subsequent chemotherapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Proteínas de Unión al ADN
/
Endonucleasas
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2008
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China