[Severe lactic acidosis caused by propofol infusion: report of one case]. / Acidosis láctica severa asociada a infusión de propofol: Caso clínico.
Rev Med Chil
; 136(1): 88-92, 2008 Jan.
Article
en Es
| MEDLINE
| ID: mdl-18483658
Propofol infusion syndrome (PRIS) is a rare but potentially lethal complications. This disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance in mitochondrial long chain fatty acid oxidation. We report a 43 year-old woman who underwent brain surgery due to a vascular malformation. In the immediate postoperative period, she had an unexplained and severe lactic acidosis. During anaesthesia, she received a propofol infusion of 7 mg/kg/h that continued in the UCI at a rate of 3.5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acidosis Láctica
/
Propofol
/
Anestésicos Intravenosos
/
Hipnóticos y Sedantes
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
Es
Revista:
Rev Med Chil
Año:
2008
Tipo del documento:
Article
Pais de publicación:
Chile