BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients.
Leuk Res
; 32(10): 1518-22, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18455790
This study was conducted to determine the frequency of the most common fusion genes in Mexican pediatric patients with acute lymphoblastic leukemia (ALL). Molecular analysis using RT-PCR was carried out in 53-blood samples: 52 patients with de novo ALL and one with relapsed ALL. The ETV6-RUNX1 fusion was found in 7 cases (13.5%), BCR-ABL fusion was detected in 2 cases (3.8%), and 6 patients (11.5%) expressed the chimeric gene E2A-PBX1. The prevalence of E2A-PBX1 is one of the highest that has been described thus far in childhood ALL. Furthermore, we detected both the BCR-ABL, and E2A-PBX1 fusion in the relapsed patient. With regards to the immunophenotype, ETV6-RUNX1 was expressed in both pre-B and T-cell cases, while the presence of E2A-PBX1 and BCR-ABL was associated with the pre-B ALL phenotype. The prevalence of E2A-PBX1 in Mexican pediatric cases supports the existence of ethnic differences in the frequency of molecular markers of ALL.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Proteínas de Fusión Oncogénica
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Proteínas de Fusión bcr-abl
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Proteínas de Homeodominio
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Proteínas Proto-Oncogénicas c-ets
/
Subunidad alfa 2 del Factor de Unión al Sitio Principal
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
/
Humans
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Infant
/
Male
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Leuk Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Reino Unido