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Association of a polymorphism of ABCB1 with obesity in Japanese individuals.
Ichihara, Sahoko; Yamada, Yoshiji; Kato, Kimihiko; Hibino, Takeshi; Yokoi, Kiyoshi; Matsuo, Hitoshi; Kojima, Tai; Watanabe, Sachiro; Metoki, Norifumi; Yoshida, Hidemi; Satoh, Kei; Aoyagi, Yukitoshi; Yasunaga, Akitomo; Park, Hyuntae; Tanaka, Masashi; Nozawa, Yoshinori.
Afiliación
  • Ichihara S; Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514-8507, Japan. saho@gene.mie-u.ac.jp
Genomics ; 91(6): 512-6, 2008 Jun.
Article en En | MEDLINE | ID: mdl-18442890
The aim of the present study was to identify gene polymorphisms that confer susceptibility to obesity. A total of 5448 unrelated Japanese individuals from two independent populations were examined: subject panel A comprised 4252 individuals who visited participating hospitals; subject panel B comprised 1196 community-dwelling elderly individuals. The genotypes for 95 polymorphisms of 67 candidate genes were determined. The chi(2) test revealed that six polymorphisms were related (p<0.05) to the prevalence of obesity in subject panel A; after application of Bonferroni's correction, however, only the 2677G --> A/T polymorphism (rs2032582) of the ATP-binding cassette, subfamily B, member 1 gene (ABCB1) was significantly associated (p=0.0003) with obesity. Subsequent multivariable logistic regression analysis also revealed that the 2677G --> A/T polymorphism of ABCB1 was significantly associated with obesity. For validation of this association, the 2677G --> A/T polymorphism of ABCB1 was examined in subject panel B and again found to be significantly associated with obesity. Body mass index was significantly (p=0.01) greater for individuals with the variant T allele of this polymorphism than for those with the GG genotype in the combined subject panels A and B. Our results suggest that the ABCB1 genotype may prove informative for assessment of genetic risk for obesity in Japanese individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Miembro 1 de la Subfamilia B de Casetes de Unión a ATP / Predisposición Genética a la Enfermedad / Pueblo Asiatico / Obesidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2008 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Miembro 1 de la Subfamilia B de Casetes de Unión a ATP / Predisposición Genética a la Enfermedad / Pueblo Asiatico / Obesidad Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2008 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos