Modification of duplex poly(G).poly(C) by platinum (II) compounds.

Platonova, G A; Kogan, E M; Sidorova, N S

Platonova, G A; Kogan, E M; Sidorova, N S.

Afiliación

Platonova GA; Institute of Macromolecular Compounds, USSR Academy of Sciences, Leningrad.

Nucleic Acids Symp Ser ; (24): 171-2, 1991.

Article en En | MEDLINE | ID: mdl-1841277

RESUMEN

The modification of the double-stranded poly(G).poly(C) complex by cis-diamminedichloroplatinum(II) was studied by two modes: the action of cis-DDP on poly(G) before formation of the duplex with poly(C) and that on the prepared duplex. It was shown that in the latter case modification disordered the integrity of the duplex only negligibly at rb less than or equal to 0.05 and led to improved interferon-inducing and antiviral activity tested on mice infected by Influenza and Herpes viruses.

Asunto(s)

Cisplatino/química; Poli C/química; Poli G/química; Conformación de Ácido Nucleico

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poli C / Poli G / Cisplatino Idioma: En Revista: Nucleic Acids Symp Ser Año: 1991 Tipo del documento: Article Pais de publicación: Reino Unido

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links