[Kinetic analysis of a transient potassium current in rat cerebellar granule cells in vitro]. / Analisi cinetica di una corrente potassio transiente nelle cellule dei granuli di cervelletto di ratto "in vitro".
Boll Soc Ital Biol Sper
; 67(12): 1015-21, 1991 Dec.
Article
en It
| MEDLINE
| ID: mdl-1840791
Thin slices were prepared from cerebella of 10-24 day old rats and examined with whole-cell patch-clamp methods. Depolarizing steps from holding potentials negative to -60 mV elicited an early transient outward current, identified as IA, and a late outward K+ current. Depolarizations from -50 mV failed to evoke any A current and gave only a slowly rising component similar to the delayed K+ current, which inactivated thereafter with a time constant of 2.5 s at -30 mV. The IA peaked in 1-2 ms, decayed following a double exponential with time constants of 8.1 and 53.2 ms at +20 mV and was half-inactivated at -82.5 mV. 4-AP 4 mM depressed both K+ currents showing little specificity between them, while TEA 20 mM selectively abolished only the delayed K+ current.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potasio
/
Potenciales de Acción
/
Corteza Cerebelosa
Límite:
Animals
Idioma:
It
Revista:
Boll Soc Ital Biol Sper
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Italia