Circumvention of glucocorticoid resistance in childhood leukemia.
Leuk Res
; 32(9): 1417-23, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18395253
In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pregnatrienos
/
Metilprednisolona
/
Leucemia Mieloide Aguda
/
Resistencia a Antineoplásicos
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Glucocorticoides
Límite:
Child
/
Humans
Idioma:
En
Revista:
Leuk Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Reino Unido