Where shall we meet? A role for genome organisation and nuclear sub-compartments in mediating interchromosomal interactions.
J Cell Biochem
; 104(5): 1553-61, 2008 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-18384074
A recent spate of examples of specific interactions between loci on separate chromosomes in mammalian nuclei has illuminated another layer of complexity in gene regulation. As the specifics of the cross-talk between interacting loci are worked out, it is also important to consider exactly how, when and where loci can ever reliably find each other within such an intricate environment. Answers may lie in how the genome is organised in relation to itself and to specialised nuclear sub-compartments. Here, we discuss how such specialised nuclear bodies may have the potential to specifically sequester loci and provide a context where interchromosomal communications can occur.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleo Celular
/
Cromosomas
/
Genoma
/
Posicionamiento de Cromosoma
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Cell Biochem
Año:
2008
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Estados Unidos