[Role of Toll-like receptors and defensins in antimicrobial protection of urogenital tract in females].
Zh Mikrobiol Epidemiol Immunobiol
; (1): 46-50, 2008.
Article
en Ru
| MEDLINE
| ID: mdl-18368752
Levels of expression of hBD-1 gene (beta-defensin 1) and Toll-like receptors (TLR1, TLR2, TLR6) in cells of cervical mucosa in healthy nonpregnant and healthy pregnant women as well as in pregnant women with urogenital infection was measured by developed RT-PCR systems. During normal pregnancy compared with nonpregnant women, increase of TLRs genes expression which was correlated with increase of hBD-1 gene expression was observed. During urogenital infection in pregnant women compared with healthy pregnant, 10- fold and 50-fold increase of TLR1 and TLR2 genes expression respectively was associated with 2.5-fold decrease of hBD-1 gene expression in cervical mucosa. In group of women with untrauterine infection more marked increase of TLRs genes expression was observed. Thus significant changes (TLRs, antimicrobial peptides, cytokines etc.) in cells of cervical mucosa can be used as prognostic criteria for development of intrauterine infection.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cuello del Útero
/
Enfermedades Transmisibles
/
Beta-Defensinas
/
Receptores Toll-Like
/
Enfermedades Urogenitales Femeninas
/
Membrana Mucosa
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Año:
2008
Tipo del documento:
Article
Pais de publicación:
Rusia