A comparison of pentane-1,5-diol to other diols for use in dermatology.
Expert Opin Investig Drugs
; 17(4): 601-10, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-18363524
BACKGROUND: The use of pentane-1,5-diol in topical pharmaceutical products is relatively new compared with, e.g., propane-1,2-diol (propylene glycol), also an aliphatic diol, which has been used for many years. Yet, what are the differences between diols in clinical efficacy, safety and other characteristics? OBJECTIVE: The objective of this overview was to compare the efficacy, safety, chemical and pharmaceutical characteristics of pentane-1,5-diol with other aliphatic diols used in pharmaceutical formulations in dermatology. METHODS: A survey of the literature was carried out based on searches limited to aliphatic diols. RESULTS/CONCLUSION: Pentane-1,5-diol was found to be safe and more effective than several other diols with respect to drug delivery-enhancing potency, pharmaceutical and cosmetic properties, antimicrobial spectrum and toxicity. Results from formal clinical trials with pentane-1,5-diol verify its efficacy and safety. These characteristics together with its low cost make pentane-1,5-diol an attractive substance for use in pharmaceutical formulations for topical administration.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conservadores Farmacéuticos
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Enfermedades Cutáneas Infecciosas
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Vehículos Farmacéuticos
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Fármacos Dermatológicos
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Glicoles
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Antiinfecciosos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Opin Investig Drugs
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
2008
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Reino Unido