[Beneficial effects of Qiangxin capsule on controlling protein expression of myocardial apoptosis in heart failure rats].
Zhong Yao Cai
; 30(11): 1411-3, 2007 Nov.
Article
en Zh
| MEDLINE
| ID: mdl-18323211
OBJECTIVE: To observe the effects of Qiangxin Capsule on myocardial apoptosis in chronic heart failure rats. METHODS: The model was established by injecting ADR in intraperitoneal of Wistar rat. The models were devided into three groups those were prvention group with Chinese medicine, treatment group with Chinese medicine and control group with medicine. Cardiac myocyte apoptosis were detected by terminal deoxynucleotidyl transferaseediated dUTP nick-end labeling (TUNEL), Fas and cardiac expression level of Bcl-2 were detected by immunohistochemistry. RESULTS: Qiangxin capsule could inhibit myocardial apoptosis and Fas protein expression on chronic heart failure rat obviously , and improve Bcl-2 protein expression. CONCLUSION: Qianxin capsule can inhibit myocardial apoptosis and control Fas/Bcl-2 obviously. It may be one of its effects in delaying chronic heart failure.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Apoptosis
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Miocitos Cardíacos
/
Insuficiencia Cardíaca
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Zhong Yao Cai
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2007
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China