Sex hormone binding globulin, cortisol binding globulin, thyroxine binding globulin, ceruloplasmin: changes in treatment with two oral contraceptives low in oestrogen.
Clin Exp Obstet Gynecol
; 18(1): 43-5, 1991.
Article
en En
| MEDLINE
| ID: mdl-1829029
ABSTRACT
PIP: The residual androgenic activity of two new combined oral contraceptives (OCs)--30 mcg of ethinyl estradiol in combination with either 150 mg of desogestrel or 75 mcg of gestodene--was investigated in 40 healthy volunteers. Measured in these volunteers were modifications in transport protein levels. These levels are known to be increased by estrogen, but this increase can be counterbalanced, to varying degrees, by gestagens. For both OCs, there was a marked percentage increase in sex hormone binding globulin (SHBG), corticosteroid binding globulin (CBG), thyroxine binding globulin (TBG), and ceruloplasmin (CP) and a similar reduction in total testosterone and the free androgen index. The modifications in SHBG, CBG, TBG, and CP are interpreted as an expression of the correlated value of the estrogenicity/gestagenicity ratio of the OCs studied and suggest that these particular formulations have greater estrogenicity. The relatively negligible biological androgenic activity of desogestrel and gestodene and their elevated affinity progesterone receptor/androgen receptor ratio reflect the high selectivity of these agents. Moreover, the lack of androgenic effects makes desogestrel and gestodene appropriate treatment agents for hyperandrogenism.
Palabras clave
Adrenal Cortex Hormones; Androgens; Biology; Blood Proteins; Clinical Research; Contraception; Contraceptive Agents, Estrogen--pharmacodynamics; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Contraceptive Methods; Desogestrel--pharmacodynamics; Endocrine System; Ethinyl Estradiol--pharmacodynamics; Family Planning; Gestodene--pharmacodynamics; Hematological Effects; Hemic System; Hormones; Oral Contraceptives; Oral Contraceptives, Combined; Physiology; Research Methodology; Serum Protein Effects; Treatment
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Seroglobulinas
/
Anticonceptivos Orales Combinados
/
Etinilestradiol
/
Norpregnenos
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
Idioma:
En
Revista:
Clin Exp Obstet Gynecol
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Singapur