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Biophysical characterization of fibroblast growth factor homologous factor-1b (FHF-1b): sodium dodecyl sulfate promotes two state folding.
Dubey, Vikash Kumar; Singh, Bishal Kumar; Sarkar, Nandini; Pande, Monu; Jagannadham, Medicherla Venkata.
Afiliación
  • Dubey VK; Department of Biotechnology, Indian Institute of Technology, Guwahati-781039, Assam, India. vdubey@iitg.ernet.in
Protein Pept Lett ; 15(2): 215-8, 2008.
Article en En | MEDLINE | ID: mdl-18289114
The current article describes the biophysical characterization and folding studies of fibroblast growth factor homologous factor-1b (FHF-1b) in comparison with acidic fibroblast growth factor (FGF-1). Our data indicates that FHF-1 is significantly more stable than FGF-1. The folding mechanism of these two proteins seems to be different although they share high degree of sequence and structural similarity. FHF-1 unfolds through stable intermediate state while unfolding of FGF-1 is two-state. Interestingly, low concentration of sodium dodecyl sulfate (SDS) drives the folding pathway of FHF-1b to two-state.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pliegue de Proteína / Factores de Crecimiento de Fibroblastos Límite: Humans Idioma: En Revista: Protein Pept Lett Asunto de la revista: BIOQUIMICA Año: 2008 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pliegue de Proteína / Factores de Crecimiento de Fibroblastos Límite: Humans Idioma: En Revista: Protein Pept Lett Asunto de la revista: BIOQUIMICA Año: 2008 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos